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You folks living in Orlando (or who can position there from another city) get some pretty decent Delta mileage runs. We just found another good one: a trip to Los Angeles (LAX) projected to earn 8,596 MQM for just over $200!
The run flies MCO-SEA-LAX-MCO and can be knocked down in just under 24 hours. It’s a Main Cabin run, which isn’t great. But you might be able to snag a First Class upgrade if you’re already a Medallion member. Otherwise, you may have to suffer for your art MQMs. 
I found September 15 available for this one.
Delta is giving 50% MQD, MQM, and MQS bonuses on flights flown through the rest of 2021. So you should end up earning 8,586 MQM, $228 MQD, and 4.5 MQS.
There are plenty of other good opportunities available through JFK and DTW for about $50 more. The $200 price is pretty tough to beat, though. That brings the CPMQM to just 2.3!
“Are There Any Good Mileage Runs from My Home Airport? What About Other Alliances?!”
You have a team of personal mileage run concierges available at Juicy Miles! Get in touch with them to create a mileage run from your favorite airport and on your preferred airline alliance.
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Maybe FC will be cheaper too??
The prices I saw weren’t anything exciting.
Unfortunately I only have a high interest in MQD runs at this point this year
First mileage run here! I ended up booking this, but since I could not use a FC upgrade on the way home, I added another day for $80 in price difference and was able to use a FC upgrade. I plan to use a free hotel night certificate to cover the overnight. Thanks for the heads up.
Our pleasure! Glad it worked for you — have a great time!